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Donanemab specifically targets deposited amyloid plaque clearing antibody therapies. This delay in progression meant that, on average, participants treated with donanemab had an additional 7. CDR-SB compared to those on placebo. Participants in TRAILBLAZER-ALZ 2 were stratified by their level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease.
